Previous research has shown that socioeconomic status (SES) is a powerful determinant of human health and disease, and social inequality is a ubiquitous stressor for human populations globally. Lower educational attainment and/or income predict increased risk for heart disease, diabetes, many cancers and infectious diseases, for example. Furthermore, lower SES is associated with physiological processes that contribute to the development of disease, including chronic inflammation, insulin resistance and cortisol dysregulation.
In this study, researchers found evidence that poverty can become embedded across wide swaths of the genome. They discovered that lower socioeconomic status is associated with levels of DNA methylation (DNAm) — a key epigenetic mark that has the potential to shape gene expression — at more than 2,500 sites, across more than 1,500 genes.
In other words, poverty leaves a mark on nearly 10 percent of the genes in the genome.
— source news.northwestern.edu | Apr 4, 2019