Patented as a flame retardant for plastics, and banned in food throughout Europe and Japan, a brominated chemical called BVO has been added to sodas for decades in North America. Now some scientists have a renewed interest in this little-known ingredient, found in 10 percent of sodas in the United States. Research on its toxicity dates back to the 1970s, and some experts now urge a reassessment. After a few extreme soda binges – not too far from what many video gamers regularly consume – a few patients have needed medical attention for skin lesions, memory loss and nerve disorders, all symptoms of overexposure to bromine. Other studies suggest that BVO could be building up in human tissues. In mouse studies, big doses caused reproductive and behavioral problems.
The next time you grab a Mountain Dew, Squirt, Fanta Orange, Sunkist Pineapple, Gatorade Thirst Quencher Orange, Powerade Strawberry Lemonade or Fresca Original Citrus, take a look at the drink’s ingredients. In Mountain Dew, brominated vegetable oil is listed next-to-last, between disodium EDTA and Yellow 5. These are just a sampling of drinks with BVO listed in their ingredients, which is required by the FDA. The most popular sodas – Coca-Cola and Pepsi – do not contain BVO.
You don’t have to be a gamer to drink these fruit-flavored sodas. In the United States, 85 percent of kids drink a beverage containing sugar or artificial sweetener at least once per week, according to a study published last month. Sodas are the largest source of calories for teenagers between the ages of 14 to 18, according to a National Cancer Institute study. For adults, soda, energy and sports drinks are the fourth largest source of calories, a federal study found.
Hold a bottle of Mountain Dew to a light. It’s cloudy. Brominated vegetable oil creates the cloudy look by keeping the fruity flavor mixed into the drink. Without an emulsifier such as BVO, the flavoring would float to the surface. The FDA limits the use of BVO to 15 parts per million in fruit-flavored beverages.
Brominated vegetable oil, which is derived from soybean or corn, contains bromine atoms, which weigh down the citrus flavoring so it mixes with sugar water, or in the case of flame retardants, slows down chemical reactions that cause a fire.
Brominated flame retardants lately are under intense scrutiny because research has shown that they are building up in people’s bodies, including breast milk, around the world. Designed to slow the spread of flames, they are added to polystyrene foam cushions used in upholstered furniture and children’s products, as well as plastics used in electronics. Research in animals as well as some human studies have found links to impaired neurological development, reduced fertility, early onset of puberty and altered thyroid hormones.
BVO may not be in use today as a flame retardant in furniture foam, but patents in Europe — granted earlier this year to Dow Global Technologies — and in the United States — granted in 1967 to Koppers Inc. — keep that possibility alive.
Soda makers and industry groups say they are not concerned about the safety of brominated vegetable oil, saying their products meet all government standards.
Some experts are unconvinced, saying that the FDA standards are based on decades-old data.
Toxicity testing has changed dramatically in the past few decades. Multiple generations of animals now can be tested for neurodevelopmental, hormonal and reproductive changes that weren’t imagined in the 1970s and early 1980s.
In 1970, scientists in England found that rats on a six-week diet containing 0.8 percent brominated maize oil had stockpiles of bromine in their fat tissue. The bromine stayed there even after the rats returned to a control diet for two weeks.
Around the same time, a study confirmed that bromine was building up in humans. Researchers measured the serum levels of people in the United Kingdom – where BVO was in use – and in their counterparts in the Netherlands and Germany, where BVO was not used.
Data in rats show that BVO could be toxic. A 1971 study by Canadian researchers found that rats fed a diet containing 0.5 percent brominated oils grew heavy hearts and developed lesions in their heart muscle. In a later study, in 1983, rats fed the same oils had behavioral problems, and those fed 1 percent BVO had trouble conceiving. At 2 percent, they were unable to reproduce.
The diets in that study had “whopping doses” of BVO, about 100-times higher than today’s allowable limit, said Vorhees, lead author of the 1983 study.
But two case studies in the past 15 years show that whopping doses also can occur in people – with unhealthy consequences.
In 1997, emergency room doctors at University of California, Davis reported a patient with severe bromine intoxication from drinking two to four liters of orange soda every day. He developed headaches, fatigue, ataxia (loss of muscle coordination) and memory loss.
Based on data from the early studies, the FDA yanked brominated vegetable oil from its Generally Recognized as Safe (GRAS) list for flavor additives in 1970, said Douglas Karas, a spokesman for the FDA. BVO bounced back after studies from an industry group from 1971 to 1974 demonstrated a level of safety.
The Flavor Extract Manufacturers’ Association petitioned the FDA to get BVO back in fruit-flavored beverages, this time as a stabilizer, which is its role today. After evaluating the petition and other data, the FDA in 1977 approved the interim use of BVO at 15 ppm in fruit-flavored beverages, pending the outcome of additional studies.
The FDA determined that a 2-year feeding study in pigs established a no-effect level of 1,200 ppm. A 2-year feeding study in beagle dogs also was conducted. Although there were concerns about quality control with that particular study, Karas said, no cardiovascular effects were observed in the dogs fed BVO at levels as high as 3,600 ppm for two years. After an independent audit of the data to address the quality concerns, the FDA decided to allow BVO in fruit-flavored beverages.
More than 30 years later, brominated vegetable oil’s approval status is still listed as interim. Changing the status would be costly.
Michael Jacobson, executive director of the Center for Science in the Public Interest, was involved with the petition to remove BVO from the “safe” list in 1970. He said it’s time for the FDA to make a decision, one way or the other.
– from environmentalhealthnews.org
Anyway, why paying money and drinking poison? Lets make food and drinks at home itself.